I have ASUS Maximus V Extreme (that I buy by MaJ0r after ending ASUS Overclocking Cup) BIOS 1604 (also try Shamino 0022) Intel Core i5-3570K 2*8G Kingston HyperX Beast XMP-1866 ASUS Radeon HD6870 OC Windows 8 x64 if I try install video driver higer than Catalyst 12.10 (188.8.131.52) than I recieve error - "cannot read from specified device" more info for russian speaking users here http://forum.asus.ru/viewtopic.php?f=1&t=87760 problem not in HD6870 - I try HD6870 on another motherboard ASUS P8B75-MLX - all drivers to Catalyst 13.2 beta 6 installed correctly and work. and I try HD6450 on my ASUS Maximus V Extreme - same error "cannot read from specified device" problem not in video drivers - why? answer: my Windos 8 x64 I use on previously configuration ASUS P5Q Premium + Intel Core 2 Quad Q9650 + ASUS U3S6 adapter + OCZ Solid3 120Gb + HD6870 on my previously configuration was installed all drivers from Catalyst 12.10 to Catalyst 13.2 beta 5 (all Catalyst 12.11 betas, Catalyst 13.1 WHQL, Catalyst 13.2 betas) I install ASUS U3S6 adapter + OCZ Solid3 120Gb + HD6870 to new ASUS Maximus V Extreme and Windows 8 up and run, founded all hardware and installed all drivers - this is beginnig of February - Catalyst 13.2 beta 5 for HD6870 up and working correctly. until Catalyst 13.2 beta 6 out and I decide to update driver. I already try anything than I can. ClearCMOS install only 4GB memory Install clean Windows 8 x64 on another SSD remove adapters nothing help - all drivers higer Catalyst 12.10 give error - "cannot read from specified device" ASUS Tech Support only ask my try that, try that - but I already try everything. also try Windows 7 - same story - all drivers higer Catalyst 12.10 give error - "cannot read from specified device"