I tried experimenting with this multiple times in the last decade, but I don't think you can do much better than Hypers on X48. Ultimately, it's all a matter of convenience - the only way to beat ambient Hypers is running cold on your memory. However, given how many more variables it adds to the troubleshooting procedure, how poorly-designed X48 boards are from reliability standpoint, and how difficult good boards are to replace in case of death, it's not really worth the effort.
Still, if we want to have a theoretical discussion:
D9GTR: single-sided sticks usually need high tRFC (60+) above 1025-ish and 1000+ capable dual-sided sticks are impossible to find (I wasn't able to do so in 11 years)
BBSE: on ambient you're likely to hit the same IMC cap as Hypers while running looser tRCD, on cold you can probably do tRCD 6 at 1000-1050 which could be interesting (given that BBSE also like tight-ish tRAS and tRFC)
BDBG / PSC: even on cold you're not likely to go below tRCD 7 at 1050, so you'll be losing to ambient Hypers, especially given that BDBG/PSC run looser tRAS and tRFC